| Autor: |
Gabriel A, Nketiah, Mattijs, Elschot, Tom W, Scheenen, Marnix C, Maas, Tone F, Bathen, Kirsten M, Selnæs, Heninrich, von Busch |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Scientific Reports |
| ISSN: |
2045-2322 |
| Popis: |
T2-weighted (T2W) MRI provides high spatial resolution and tissue-specific contrast, but it is predominantly used for qualitative evaluation of prostate anatomy and anomalies. This retrospective multicenter study evaluated the potential of T2W image-derived textural features for quantitative assessment of peripheral zone prostate cancer (PCa) aggressiveness. A standardized preoperative multiparametric MRI was performed on 87 PCa patients across 6 institutions. T2W intensity and apparent diffusion coefficient (ADC) histogram, and T2W textural features were computed from tumor volumes annotated based on whole-mount histology. Spearman correlations were used to evaluate association between textural features and PCa grade groups (i.e. 1–5). Feature utility in differentiating and classifying low-(grade group 1) vs. intermediate/high-(grade group ≥ 2) aggressive cancers was evaluated using Mann–Whitney U-tests, and a support vector machine classifier employing “hold-one-institution-out” cross-validation scheme, respectively. Textural features indicating image homogeneity and disorder/complexity correlated significantly (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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