| Autor: |
Catherine J, Wei, Christiane, Linster, Thomas A, Cleland |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
Behavioral neuroscience. 120(2) |
| ISSN: |
0735-7044 |
| Popis: |
Dopaminergic modulation affects odor detection thresholds and olfactory discrimination capabilities in rats. The authors show that dopamine D(2) receptor modulation affects odor discrimination capabilities in a manner similar to the modulation of stimulus intensity. Performance in a simultaneous odor discrimination task was systematically altered by manipulations of both odorant concentration and D(2) receptor activation (agonist quinpirole, 0.025-0.5 mg/kg; antagonist spiperone, 0.5 mg/kg). Rats' discrimination performance systematically improved at higher odor concentrations. Blockade of D(2) receptors improved performance equivalent to increasing odor concentration by 2 log units, whereas activation of D(2) receptors reduced odor discrimination performance in a dose-dependent manner. Bulbar dopamine release may serve a gain control function in the olfactory system, optimizing its sensitivity to changes in the chemosensory environment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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