Distinct properties of fenretinide and CD437 lead to synergistic responses with chemotherapeutic reagents

Autor:	P E, Lovat, M, Ranalli, F, Bernassola, M, Tilby, A J, Malcolm, A D, Pearson, M, Piacentini, G, Melino, C P, Redfern
Rok vydání:	2000
Předmět:	Neuroblastoma Retinoids Fenretinide Free Radicals Tumor Cells Cultured Humans Antineoplastic Agents Apoptosis Drug Synergism Child
Zdroj:	Medical and pediatric oncology. 35(6)
ISSN:	0098-1532
Popis:	The RARbeta/gamma-selective retinoids fenretinide and CD437 induce caspase-dependent apoptosis but generate free radicals independently of caspases. Apoptosis, but not free radical generation, induced by these retinoids is inhibited by RARbeta/gamma-specific antagonists. Both fenretinide and CD437 induce apoptosis synergistically with cisplatin, carboplatin, or etoposide. However, antioxidants inhibit this synergy to the level obtained with chemotherapeutic drugs alone, and this implies that free radical generation is important in the synergistic response. Since apoptosis induced by fenretinide or CD437 is mediated by apoptotic pathways involving RARs and/or mitochondria and differs from mechanisms of chemotherapy-induced apoptosis this may explain the strong synergistic response seen between these synthetic retinoids and chemotherapeutic drugs. These results suggest that fenretinide or CD437 may be useful adjuncts to neuroblastoma therapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::38634d8bfc174b65a6f710c6d30aab35 https://pubmed.ncbi.nlm.nih.gov/11107142 Zobrazit plný text záznamu Plný text