| Autor: |
F, Ramirez, L B, Travis, R J, Cunningham, T, Cavallo, S, Rajarman, B H, Brouhard, E N, Ellis |
| Rok vydání: |
1982 |
| Předmět: |
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| Zdroj: |
The International journal of pediatric nephrology. 3(3) |
| ISSN: |
0391-6510 |
| Popis: |
The usual clinical course of focal segmental glomerulosclerosis is marked by progressive decrease in renal functional and sclerosis on biopsy over a period of months to years. We report a variant exemplified by 2 children who developed chronic renal failure within 12 weeks of the onset of nephrotic syndrome; repeat renal biopsies demonstrated extensive extracapillary glomerular proliferation and crescent formation. Both were males, less than 5 years of age, presenting with nephrotic syndrome resistant to steroid therapy and normal renal function. Renal biopsies done after 8 weeks of therapy, demonstrated findings compatible with focal segmental glomerulosclerosis. Within 12 weeks of onset of nephrotic syndrome, both patients experienced a decrease in renal function requiring dialysis. Repeat renal biopsies revealed extensive extracapillary glomerular proliferation with crescent formation. These patients represent a variant of focal segmental glomerulosclerosis characterized by rapid progression to renal failure with extensive extracapillary glomerular proliferation and crescent formation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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