[Type-specific antibodies to hepatitis C virus in sera from patients with various hematologic diseases]

Autor:	T A, Garanzha, T A, Tupoleva, A A, Guliaeva, T V, Firsova, Iu A, Semiletov, T I, Alekseenkova, M V, Ianina, T V, Golosova, V A, Shibnev, F P, Filatov
Rok vydání:	2001
Předmět:	Immunoenzyme Techniques Epitopes Immunoblotting Molecular Sequence Data Humans Blood Donors Amino Acid Sequence Hepacivirus Viral Nonstructural Proteins Antibodies Viral Hematologic Diseases Peptide Fragments
Zdroj:	Zhurnal mikrobiologii, epidemiologii i immunobiologii. (2)
ISSN:	0372-9311 1683-1705
Popis:	The reactivity of 100 sera taken from patients with different blood diseases and donors with respect to synthesized peptides in the variable area of protein NS4 of hepatitis C virus was studied. The presence of type-specific antibodies in the blood sera of patients with hepatitis C was shown. Two antigenic determinant corresponding to 1683-1705 and 1711-1732 amino acid residues in the protein area under study were detected. In hematological patients undergoing frequent blood transfusions mixed infection with different types of hepatitis C virus was registered; these types could be reliably determined with the use of synthetic peptides. The serotype determined with the use of peptides corresponded to the type of the circulating virus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3853fd180d8fc2f328f7b98a072c6fb4 https://pubmed.ncbi.nlm.nih.gov/11548266 Zobrazit plný text záznamu