Analysis of Trimethoprim--sulfonamide drug combinations in dosage forms by UV spectroscopy and liquid chromatography (HPLC)

Autor:	D, Bonazzi, V, Andrisano, A M, Di Pietra, V, Cavrini
Rok vydání:	1994
Předmět:	Drug Combinations Sulfamethoxazole Sulfadiazine Capsules Spectrophotometry Ultraviolet Hydrogen-Ion Concentration Sulfamethoxypyridazine Chromatography High Pressure Liquid Trimethoprim Tablets
Zdroj:	Farmaco (Societa chimica italiana : 1989). 49(6)
ISSN:	0014-827X
Popis:	Derivative and difference spectrophotometric methods are described for the direct simultaneous analysis of combinations of Trimethoprim with sulfonamide drugs (sulfadiazine, sulfamethoxazole, sulfamethoxypyridazine) in commercial dosage forms. The more advantageous approach (derivative and difference mode) is suggested for each binary mixture. The assay results are compared with those obtained by a new chromatographic (HPLC) method, involving a C-18 column and a mobile phase (pH 6.5) containing 1.8 diaminooctane as amine modifier and sodium heptansulfonate as ion pairing agent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::3850e4bb7484ed31b2476b58650424cb https://pubmed.ncbi.nlm.nih.gov/8074781 Zobrazit plný text záznamu