| Autor: |
F I, Ershov, V I, Sumin, A M, Saĭitkulov, N I, Baram, E B, Tazulakhova, A I, Ismailov |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 37(1) |
| ISSN: |
0235-2990 |
| Popis: |
The pharmacokinetics of PHL-6 and interferon synthesis dynamic in the target organs (tissues) of mice were studied during its and intraperitoneal administration. In the experimental setting, there was a direct correlation between the interferon production in the murine organs with single PHL-6 and distribution of 14C PHL-6. The highest radioactivity with its oral administration was detected in the liver and intestine. Interferon was actively synthesized in the intestine, liver and serum, showing the levels of 20000, 1024-2048 and 512-1024 IU/ml, respectively. The prolonged action of the drug was in good agreement with the low PHL-6 excretion from the body. It was also shown that almost the whole radiation dose 1 (greater than 98%) was excreted with feces and urine after single and chronic administrations of uniformly labeled PHL-6 which proved important clinical drug use. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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