| Autor: |
L Y, Hu, T R, Ryder, M F, Rafferty, K M, Siebers, T, Malone, A, Chatterjee, M R, Feng, S M, Lotarski, D M, Rock, S J, Stoehr, C P, Taylor, M L, Weber, G P, Miljanich, E, Millerman, B G, Szoke |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Drug design and discovery. 17(1) |
| ISSN: |
1055-9612 |
| Popis: |
Several novel N-type voltage sensitive calcium channel blockers showed high affinity in the IMR32 assay and efficacy in the anti-writhing model. Herein, we describe the design, synthesis, SAR studies, biological data, physicochemical properties and pharmacokinetics of this 4-piperidinylaniline series. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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