Sugar derivatives and liver mitochondria. II. Effect of beta-penta-O-acetyl-D-galactopyranose

Autor:	G M, Chagas, M, Alvarez, J H, Duarte, A P, Campello, D O, Voss
Rok vydání:	1979
Předmět:	Galactosides Mitochondria Liver In Vitro Techniques Mitochondria Heart Rats Electron Transport Succinate Dehydrogenase Adenosine Triphosphate Oxygen Consumption Animals Calcium Cattle Glycosides Energy Metabolism Mitochondrial Swelling Oxidation-Reduction
Zdroj:	Research communications in chemical pathology and pharmacology. 25(1)
ISSN:	0034-5164
Popis:	beta-penta-O-acetyl-D-galactopyranose stimulated succinate oxidation in intact liver mitochondria (100%), in broken mitochondria (50%) and in EP1 particles (20%), no effect was observed on purified succinic dehydrogenase. This compound enhances the oxidation of succinate in the presence of Ca2+ and ATP; no effect appeared in the absence of calcium. beta penta-O-acetyl-D-galactopyranose prevents the reversal of Ca2+-induced swelling by EGTA. It seems that this sugar derivative would act, in some way, in the efflux of calcium from mitochondria leading to an accumulation of this bivalent ion in the mitochondria.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::381a9766ef38b8b664ccae3f8f5af155 https://pubmed.ncbi.nlm.nih.gov/451346 Zobrazit plný text záznamu