| Autor: |
Aya M, Al-Rahim, Rawaa, AlChalabi, Ali Z, Al-Saffar, Ghassan M, Sulaiman, Salim, Albukhaty, Tareg, Belali, Elsadig M, Ahmed, Khalil A A, Khalil |
| Rok vydání: |
2021 |
| Zdroj: |
Animal biotechnology. |
| ISSN: |
1532-2378 |
| Popis: |
The study planned to estimate biological parameters linked to rheumatoid arthritis (RA) patients, detecting the influence of MTX and biotherapy treatments on these parameters and synthesizing methotrexate bovine serum albumin nanoparticles linked to folate (FA-MTX-BSA NPs) to reduce the overwhelming expression of inflammatory cytokines. Inflammatory parameters showed significant increases in newly diagnosed and MTX-receiving groups while no changes were observed in the biotherapy-maintained group. MTX-loaded BSA nanoparticles were fabricated by the desolvation method and further linked to activated folic acid to obtain FA-MTX-BSA NPs. FA-MTX-BSA NPs were successfully characterized within the nanoscale range using different screening techniques. FA-MTX-BSA NPs showed an |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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