| Autor: |
Seyed Mohammadmehdi, Hosseini-Moghaddam, Hossein, Keyvani, Ata, Soleimanirahbar, Gharib, Karimi, Simin, Daneshvar, Abbas, Basiri, Zahra, Razzaghi, Mohsen, Nafar, Fatemeh, Pour-Reza-Gholi, Soudabeh, Farhangi |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Archives of Iranian medicine. 16(7) |
| ISSN: |
1735-3947 |
| Popis: |
Different reports from Middle East countries demonstrated Kaposi's sarcoma (KS) in transplant population. This vascular malignancy occurs mostly among immunocompromised individuals. Human herpesvirus 8 (HHV-8) appears to be the causative factor for the development of this neoplasm. Transplant programs are concerned about the frequencies of HHV-8 infection either in general population or transplant patients.The current study was conducted in two phases. Firstly, we detected antibodies against HHV-8 in 790 otherwise healthy blood donors. Secondly, a total of 125 kidney allograft recipients evaluated as being seropositive for HHV-8. We utilized enzyme immunoassay (EIA) for serologic studies.Among blood donors, the male to female ratio was 1.05 (405 vs. 385 ) while the mean age was 38.9 ± 11.7 years. The serostatus of none of these blood donors were positive for HHV-8. Among kidney recipients, the male to female ratio was 1.9 (82 vs. 43). The mean age was 39.01 ± 14.77 years. Two (1.6%) patients were seropositive for HHV-8.The prevalence of HHV-8 infection among Iranians is likely to be low. Yet, owing to the evidence of this infection among kidney allograft recipients and its probable role in developing post- transplantation KS (PT-KS), further studies appear to be required to keep the various aspects of this infection under close surveillance. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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