Human stem cell-derived astrocytes replicate human prions in a

Autor:	Zuzana, Krejciova, James, Alibhai, Chen, Zhao, Robert, Krencik, Nina M, Rzechorzek, Erik M, Ullian, Jean, Manson, James W, Ironside, Mark W, Head, Siddharthan, Chandran
Rok vydání:	2016
Předmět:	Adult Male Genotype Prions animal diseases Induced Pluripotent Stem Cells Middle Aged News Insights Creutzfeldt-Jakob Syndrome Prion Proteins nervous system diseases Kinetics Young Adult Astrocytes Humans Female Codon Cells Cultured
Zdroj:	The Journal of Experimental Medicine
ISSN:	1540-9538
Popis:	In this issue of JEM, Krejciova et al. report that astrocytes derived from human iPSCs can replicate human CJD prions. These observations provide a new, potentially very valuable model for studying human prions in cellula and for identifying antiprion compounds that might serve as clinical candidates. Furthermore, they add to the evidence that astrocytes may not be just innocent bystanders in prion diseases. In this issue of JEM, Krejciova et al. (https://doi.org/10.1084/jem.20161547) report that astrocytes derived from human iPSCs can replicate human CJD prions. These observations provide a new, potentially very valuable model for studying human prions in cellula and for identifying antiprion compounds that might serve as clinical candidates. Furthermore, they add to the evidence that astrocytes may not be just innocent bystanders in prion diseases.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::378bcc9a9c72f9251ba609d903bb7be0 https://pubmed.ncbi.nlm.nih.gov/29162644 Zobrazit plný text záznamu