Interferon-γ production by tubulointerstitial human CD56
| Autor: | Becker M P, Law, Ray, Wilkinson, Xiangju, Wang, Katrina, Kildey, Mae, Lindner, Melissa J, Rist, Kenneth, Beagley, Helen, Healy, Andrew J, Kassianos |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Antigens Differentiation T-Lymphocyte Male Natural Cytotoxicity Triggering Receptor 1 Biopsy Fluorescent Antibody Technique Middle Aged Flow Cytometry Lymphocyte Activation Fibrosis CD56 Antigen Killer Cells Natural Interferon-gamma Proto-Oncogene Proteins c-kit Kidney Tubules Antigens CD Case-Control Studies Disease Progression Humans Female Lectins C-Type Renal Insufficiency Chronic Aged Signal Transduction |
| Zdroj: | Kidney international. 92(1) |
| ISSN: | 1523-1755 |
| Popis: | Natural killer (NK) cells are a population of lymphoid cells that play a significant role in mediating innate immune responses. Studies in mice suggest a pathological role for NK cells in models of kidney disease. In this study, we characterized the NK cell subsets present in native kidneys of patients with tubulointerstitial fibrosis, the pathological hallmark of chronic kidney disease. Significantly higher numbers of total NK cells (CD3 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|