| Autor: |
Soo Jeong, Koh, Yangsoo, Jang, Yae Jung, Hyun, Ju Yeon, Park, Young Duk, Song, Kyung-Kyun, Shin, Jey Sook, Chae, Byung-Keuk, Kim, Jose M, Ordovas, Jong Ho, Lee |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Clinical endocrinology. 70(2) |
| ISSN: |
1365-2265 |
| Popis: |
Increased levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with type 2 diabetes (T2DM). We investigated the association of IL-6 gene polymorphisms with T2DM and circulating levels of IL-6 in Koreans.A total of 1477 subjects with normal glucose tolerance and 476 T2DM patients were included.We examined IL-6 -174G--C, -572C--G, -597G--A and -1363G--T promoter region polymorphisms. The main outcome measures were the odds ratio (OR) on T2DM risk and serum concentrations of IL-6 and high-sensitivity C-reactive protein (hs-CRP).Homozygosity for the rare G allele IL-6 -572C--G was associated with a higher risk of T2DM [OR 1.69 (95%CI 1.11-2.58), P = 0.015]. Serum IL-6 concentrations were associated with the IL-6 -572C--G genotype in control subjects (G/G: 2.33 +/- 0.41: C/G: 1.53 +/- 0.09: C/C: 1.72 +/- 0.08 ng/l, P = 0.023). Also in the control group, subjects homozygous for the rare G allele showed significantly higher concentrations of hs-CRP than C/C and C/G carriers (G/G: 13.6 +/- 2.9: C/G: 9.2 +/- 0.6: C/C: 7.8 +/- 0.4 mg/l, P = 0.003). The C-allele at the IL-6 -174 SNP was very rare (0.01) and -597G--A and -1363G--T were monomorphic in this population.Our data demonstrate that the IL-6 -572G/G genotype is associated with higher serum IL-6 and hs-CRP concentrations and with increased risk for T2DM. |
| Databáze: |
OpenAIRE |
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