[Mathematical model of the effect of glucocorticoids on the movement and proliferation kinetics of mammalian lymphocytes]

Autor:	N V, Stepanova, T V, Feofanova
Rok vydání:	1984
Předmět:	Killer Cells Natural Immunity Cellular Kinetics Mice Cell Movement T-Lymphocytes Animals Bone Marrow Cells Organ Size Thymus Gland Glucocorticoids Cell Division Spleen
Zdroj:	Biofizika. 29(3)
ISSN:	0006-3029
Popis:	Effect of glucocorticoids on proliferation, death and migration of T-lymphocytes was studied by mathematical methods. A model of the interaction between hormone and thymus T1-lymphocytes is proposed which imitates involution of lymphoid tissue under stress. There were constructed models of migrations of free and radioactive chromium labeled lymphocytes in lymphoid and non-lymphoid organs, blood and lymph at arbitrary concentration of glucocorticoids in the blood. Possible mechanisms of immunodepression due to increased hormone concentrations in the organism are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::372b9688130cf9431e6727ce6b254cb0 https://pubmed.ncbi.nlm.nih.gov/6331852 Zobrazit plný text záznamu