| Autor: |
C N, Baxevanis, G J, Reclos, P, Arsenis, A, Katsiyiannis, N, Matikas, M, Papamichail |
| Rok vydání: |
1988 |
| Předmět: |
|
| Zdroj: |
Advances in experimental medicine and biology. 237 |
| ISSN: |
0065-2598 |
| Popis: |
We have recently demonstrated that peripheral blood monocytes from patients with multiple sclerosis (MS) have a defect in stimulating autologous and allogeneic T lymphocytes. This defect was found to correlate with disease activity. We report here that T4+ cells from MS patients proliferate weakly in the autologous mixed lymphocyte reaction (autoMLR). Furthermore, we provide direct proof that the depressed T4+ cell proliferation is due to the monocyte functional (stimulatory) defect. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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