The mouse CD69 gene. Structure, expression, and mapping to the NK gene complex
| Autor: | S F, Ziegler, S D, Levin, L, Johnson, N G, Copeland, D J, Gilbert, N A, Jenkins, E, Baker, G R, Sutherland, A L, Feldhaus, F, Ramsdell |
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| Rok vydání: | 1994 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte Chromosomes Human Pair 12 Base Sequence Genetic Linkage T-Lymphocytes Molecular Sequence Data Chromosome Mapping Gene Expression Thymus Gland Lymphocyte Activation Mice Genes Antigens CD Animals Humans Lectins C-Type Amino Acid Sequence RNA Messenger Cloning Molecular Promoter Regions Genetic |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 152(3) |
| ISSN: | 0022-1767 |
| Popis: | CD69 is a rapidly induced T cell activation Ag that is also expressed in an inducible fashion on cells of most, if not all, hematopoietic lineages. Molecular cloning has shown that CD69 is a type II membrane glycoprotein that is a member of the C-type lectin family. In this report we have shown that induction of CD69 mRNA in activated murine thymocytes and T cells is very rapid, peaking between 30 and 60 min poststimulation, and transient, dropping to nearly resting levels by 8 h. An analysis of the mouse CD69 gene structure showed the gene to consist of 5 exons and have a phorbol ester-inducible promoter element within the first 700 bp upstream of the start of transcription. Chromosomal mapping placed the mouse CD69 gene on the long arm of chromosome 6 near the NK gene complex that contains the related NKR-P1 and Ly-49 gene families. The human CD69 gene mapped to chromosome 12p13 near the related NKG2 gene cluster and in a region associated with rearrangements in approximately 10% of cases of childhood acute lymphocytic leukemia. |
| Databáze: | OpenAIRE |
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