| Autor: |
Nicholas R, Steffen, Scott D, Murphy, Richard H, Lathrop, Michael L, Opel, Lorenzo, Tolleri, G Wesley, Hatfield |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
Genome informatics. International Conference on Genome Informatics. 13 |
| ISSN: |
0919-9454 |
| Popis: |
We examine the use of deformation propensity at individual base steps for the identification of DNA-protein binding sites. We have previously demonstrated that estimates of the total energy to bend DNA to its bound conformation can partially explain indirect DNA-protein interactions. We now show that the deformation propensities at each base step are not equally informative for classifying a sequence as a binding site, and that applying non-uniform weights to the contribution of each base step to aggregate deformation propensity can greatly improve classification accuracy. We show that a perceptron can be trained to use the deformation propensity at each step in a sequence to generate such weights. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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