| Autor: |
Philipp E, Hartrampf, Franz-Xaver, Weinzierl, Andreas K, Buck, Steven P, Rowe, Takahiro, Higuchi, Anna Katharina, Seitz, Hubert, Kübler, Andreas, Schirbel, Markus, Essler, Ralph A, Bundschuh, Rudolf A, Werner |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
European journal of nuclear medicine and molecular imaging. 49(9) |
| ISSN: |
1619-7089 |
| Popis: |
Labelled with lutetium-177, the urea-based small molecules PSMA IT and PSMA-617 are the two agents most frequently used for radioligand therapy (RLT) in patients with advanced metastatic castration-resistant and prostate-specific membrane antigen (PSMA) expressing prostate cancer (mCRPC). In this matched-pair analysis, we aimed to compare the toxicity and efficacy of both agents for PSMA-directed RLT.A total of 110 mCRPC patients from two centres were accrued, 55 individuals treated with [Toxicity assessment revealed grade III anaemia in a single patient (1.8%) for [In this matched-pair analysis of patients receiving one of the two agents most frequently applied for PSMA RLT, the rate of clinically relevant toxicities was low for both compounds. In addition, no relevant differences for OS were observed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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