| Autor: |
Alejandro, Aguayo-Reyes, Mario, Quezada-Aguiluz, Sergio, Mella, Gisela, Riedel, Andrés, Opazo-Capurro, Helia, Bello-Toledo, Mariana, Domínguez, Gerardo, González-Rocha |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia. 35(1) |
| ISSN: |
0717-6341 |
| Popis: |
Staphylococcus aureus isolates resistant to several antimicrobials have been gradually emerged since the beginning of the antibiotic era. Consequently, the first isolation of methicillin-resistant S. aureus occurred in 1960, which was described a few years later in Chile. Currently, S. aureus resistant to antistaphylococcal penicillins is endemic in Chilean hospitals and worldwide, being responsible for a high burden of morbidity and mortality. This resistance is mediated by the expression of a new transpeptidase, named PBP2a or PBP2', which possesses lower affinity for the β-lactam antibiotics, allowing the synthesis of peptidoglycan even in presence of these antimicrobial agents. This new enzyme is encoded by the mecA gene, itself embedded in a chromosomal cassette displaying a genomic island structure, of which there are several types and subtypes. Methicillin resistance is mainly regulated by an induction mechanism activated in the presence of β-lactams, through a membrane receptor and a repressor of the gene expression. Although mec-independent methicillin resistance mechanisms have been described, they are clearly infrequent. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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