DR2/DQw1 inheritance and haplotype sharing in affected siblings from multiple sclerosis families

Autor:	R R, Voskuhl, A M, Goldstein, T, Simonis, R J, Davey, H F, McFarland
Rok vydání:	1996
Předmět:	Male Heterozygote Multiple Sclerosis HLA-DQ Antigens Humans Female HLA-DR Antigens Alleles Pedigree
Zdroj:	Annals of neurology. 39(6)
ISSN:	0364-5134
Popis:	Although the human leukocyte antigen DR2/DQw1 allele has been associated with multiple sclerosis, studies of DR2/DQw1 inheritance in multiple sclerosis multiplex families have yielded conflicting results. We examined this question in "high-incidence" families, defined as families with more than 50% of siblings affected. DR2/DQw1 allele frequencies were significantly increased, particularly in mothers and affected siblings (p0.0001). The transmission of DR2/DQw1 from both parents was more frequent in affected offspring (p = 0.005). While evidence for segregation of disease with a particular parental allele was lacking in most families, the frequency of haplotype sharing was higher in affected sib pairs (p0.01).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::365621cd1d9d32154a31d6a7b07f7cbe https://pubmed.ncbi.nlm.nih.gov/8651654 Zobrazit plný text záznamu Plný text