[Depressant effect of Lithium on apoptosis of nerve cells of adult rats after spinal cord injury]

Autor: Fang, Wang, Chao, Zhou, Zheng-Chao, Gao, Yu-Huan, Li, Wen-Long, Yang, Dong, Wang, Hao-Peng, Li, Xi-Jing, He
Rok vydání: 2017
Předmět:
Zdroj: Zhongguo gu shang = China journal of orthopaedics and traumatology. 31(4)
ISSN: 1003-0034
Popis: To study whether lithium agent produces neuroprotective effect by inhibiting the nerve cell apoptosis of rats after spinal cord injury.Forty-two male SD rats weighing 200 to 250 g were randomly divided into 3 groups: blank control group(The BBB scores in blank control group were 21. Postoperative 7, 14 d, BBB scores of Licl group were higher than that of NS group(Licl can promote the Bcl-2 protein expression and inhibit the Bax proteins expression in nerve cells of rat after SCI, thereby playing a role in the inhibition of nerve cell apoptosis. This may be one of the mechanisms that Licl can promote the recovery of motor function of rats after SCI.
Databáze: OpenAIRE