| Autor: |
Y, Kuwashima, M, Kurosumi, Y, Kobayashi, J, Tanuma, K, Suemasu, Y, Higashi, T, Kasamatsu, K, Shiromizu, M, Matsuzawa, K, Kishi |
| Rok vydání: |
1996 |
| Předmět: |
|
| Zdroj: |
Anticancer research. 16(5A) |
| ISSN: |
0250-7005 |
| Popis: |
Seven cases of endometrial adenocarcinoma patients who had experienced long-term tamoxifen treatments as adjuvant therapy of breast carcinoma, were investigated with respect to estrogen receptor (ER) status. Four cases of endometrial adenocarcinoma without tamoxifen treatment but with a previous history of breast carcinoma were investigated for comparison. One of the 7 and two of the 4 cases were positive for ER immunohistochemically. Thus, the frequency of ER positivity in secondary endometrial adenocarcinoma seemed to be at random among tamoxifen-treated and non-treated breast cancer patients. These results suggest that tamoxifen-mediated human endometrial carcinogenesis may not involve estrogenic pathway(s) but may involve other carcinogenic mechanisms such as DNA adduct formation as shown in rat liver tumorigenesis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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