Successful allogeneic bone marrow transplantation in an adult with aplastic anemia following orthotopic liver transplantation for non-A, non-B, non-C hepatitis
| Autor: | M J, Dugan, D A, Rouch, L P, Akard, B G, Sperl, J R, Black, R E, Markham, J, Jansen |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Lymphatic Irradiation Bone Marrow Purging Drug Resistance Anemia Aplastic Granulocyte-Macrophage Colony-Stimulating Factor Hepatitis C Liver Transplantation Postoperative Complications Cytomegalovirus Infections Humans Immunologic Factors Viremia Cyclophosphamide Ganciclovir Bone Marrow Transplantation |
| Zdroj: | Bone marrow transplantation. 12(4) |
| ISSN: | 0268-3369 |
| Popis: | A 29-year-old male patient presented with acute liver failure from non-A, non-B and non-C hepatitis, necessitating orthotopic liver transplantation. After operation he developed progressive pancytopenia on the basis of aplastic anemia, which was probably hepatitis associated. After therapy with GM-CSF had failed, he underwent allogeneic BMT from his HLA genotypically identical brother following a conditioning regimen of CY 50 mg/kg x 4 and 500 cGy total lymphoid irradiation. He engrafted promptly but transfusion dependency did not resolve until CMV viremia was treated with ganciclovir. The patient is alive and well 2 years after BMT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|