| Autor: |
Kazuo, Kitagawa, Hisatomi, Arima, Yasumasa, Yamamoto, Shinichiro, Ueda, Hiromi, Rakugi, Takahide, Kohro, Koji, Yonemoto, Masayasu, Matsumoto, Takao, Saruta, Kazuyuki, Shimada, Seigo, Nakada |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Hypertension research : official journal of the Japanese Society of Hypertension. 45(4) |
| ISSN: |
1348-4214 |
| Popis: |
The Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study and its pooled analysis showed that intensive blood pressure (BP) lowering reduced recurrent stroke risk by 22% in patients with a history of stroke. Here, we report the effect of intensive BP lowering on the risk of recurrent stroke subtypes in patients with a history of ischemic stroke. RESPECT was a randomized clinical trial among 1280 people with a history of cerebral infarction or intracerebral hemorrhage. Participants were assigned to the intensive blood pressure control group (blood pressure120/80 mmHg) or standard blood pressure control group (blood pressure140/90 mmHg). In this post hoc analysis, we analyzed 1074 patients with a history of cerebral infarction. The mean BP at baseline was 140.7/81.4 mmHg. Throughout the follow-up period, the mean BP was 133.4/77.5 (95% CI, 132.7-134.1/76.9-78.2) mmHg in the standard group and 126.7/74.1 (95% CI, 126.0-127.4/73.5-74.8) mmHg in the intensive group. During a mean follow-up of 3.9 years, 78 first recurrent strokes occurred. Intensive treatment tended to reduce overall annual stroke recurrence (1.74% in intensive vs. 2.17% in standard; P = 0.351 by log-rank test) and did not change the risk of ischemic stroke (1.74% vs. 1.75%, P = 0.999) but markedly reduced the risk of hemorrhagic stroke (0.00% vs. 0.39%, P = 0.005). Beneficial effects of intensive BP control were observed for the risk of hemorrhagic stroke in patients with a history of ischemic stroke. The findings of this study indicate the benefit of intensive BP control for patients with a history of ischemic stroke at high risk of hemorrhagic stroke. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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