Model-Based Once-Daily Darunavir/Ritonavir Dosing Recommendations in Pediatric HIV-1-Infected Patients Aged ≥3 to12 Years

Autor: A, Brochot, T N, Kakuda, T, Van De Casteele, M, Opsomer, F L, Tomaka, A, Vermeulen, P, Vis
Rok vydání: 2015
Předmět:
Zdroj: CPT: Pharmacometrics & Systems Pharmacology
ISSN: 2163-8306
Popis: An existing population pharmacokinetic model of darunavir in adults was updated using pediatric data from two studies evaluating weight-based, once-daily dosing of darunavir/ritonavir (ARIEL, NCT00919854 and DIONE, NCT00915655). The model was then used to provide once-daily dosing recommendations for darunavir/ritonavir in pediatric patients aged ≥3 to
Databáze: OpenAIRE