Feasibility of prenatal diagnosis of beta-thalassemia using two highly polymorphic microsatellites 5' to the beta-globin gene

Autor:	G, Loudianos, A, Cao, M, Pirastu
Rok vydání:	1992
Předmět:	Genetic Markers Base Sequence Molecular Sequence Data beta-Thalassemia DNA Satellite Polymerase Chain Reaction Globins Fetal Diseases Genes Pregnancy Prenatal Diagnosis Feasibility Studies Humans Female Repetitive Sequences Nucleic Acid
Zdroj:	Haematologica. 77(4)
ISSN:	0390-6078
Popis:	Short tandem repeats (STRs) are highly informative loci within the human genome, consisting of short nucleotide sequences tandemly repeated in variable numbers. This results in different alleles of variable length. Herein we describe two STRS located 5' to the beta-globin gene. They can be detected by non radioactive methods and may be used to make prenatal diagnosis of beta-thalassemia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::35c7c30f0c7eb12f0811bdfe5e63113c https://pubmed.ncbi.nlm.nih.gov/1427447 Zobrazit plný text záznamu