| Autor: |
M M, Liubinskaia, Iu L, Subbotina, E V, Chernokhvostova |
| Rok vydání: |
1984 |
| Předmět: |
|
| Zdroj: |
Zhurnal mikrobiologii, epidemiologii i immunobiologii. (11) |
| ISSN: |
0372-9311 |
| Popis: |
Mice received S. sonnei O-antigen at various concentrations (0.01-20,000 micrograms/ml) in drinking water. Systemic immunological memory, induced by feeding with O-antigen, was manifested by secondary immune response to parenteral boosting with homologous O-antigen or ribosomal vaccine. A pronounced priming effect was also produced by O-antigen at concentrations as low as 0.01 micrograms/ml after courses of feeding as short as 1-3 days. Even high doses of the antigen had no tolerogenic activity. The state of immunological memory was formed at least 12 days after the first feeding and lasted for a long period (at least 4 months after the last feeding). The specificity of immunological memory was proved in experiments with heterologous O-antigen (Salmonella typhimurium): the insignificant stimulating action of this antigen was revealed only when high concentrations of the antigen (1000 micrograms/ml) were used for feeding. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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