Delayed haemolytic transfusion reaction caused by anti-M antibody in a patient receiving interleukin-2 and interferon for metastatic renal cell cancer

Autor:	N, Parry-Jones, M E, Gore, J, Taylor, J G, Treleaven
Rok vydání:	2000
Předmět:	Adult Male Immunoglobulin M Humans Interferon-alpha Interleukin-2 Transfusion Reaction Antineoplastic Agents Blood Transfusion Neoplasm Metastasis Carcinoma Renal Cell Hemolysis Kidney Neoplasms
Zdroj:	Clinical and laboratory haematology. 21(6)
ISSN:	0141-9854
Popis:	Anti-M is usually a naturally occurring cold-reactive immunoglobulin M (IgM) antibody, often with an immunoglobulin G (IgG) component, and is seldom implicated in delayed haemolytic transfusion reactions (DHTR). However, cases have been reported. In the majority, a DHTR is not suspected until further blood is requested and a new antibody is detected on pretransfusion testing. We describe the case of a young man receiving therapy with interleukin-2 (IL-2) and interferon-alpha (IFN-alpha) for metastatic renal cell cancer who developed a clinically suspected DHTR that was confirmed serologically to be caused by anti-M, reactive at 37 degrees C. We discuss the possible role of his biochemotherapy in the development of the DHTR.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::35b2efc6b46f8899f9a7faf0a42824c8 https://pubmed.ncbi.nlm.nih.gov/10671995 Zobrazit plný text záznamu Plný text