| Autor: |
M H, Cobb, J E, Hepler, M, Cheng, D, Robbins |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Seminars in cancer biology. 5(4) |
| ISSN: |
1044-579X |
| Popis: |
The MAP kinases are ubiquitous enzymes that are activated in a complex fashion and inactivated by multiple phosphatases including a dedicated dual specificity enzyme. These kinases have a diverse array of substrates with important functions that result in their substantial regulatory impact. The ERK/MAP kinase cascade displays not only downstream but also upstream interactions as well as cross talk with other signaling pathways which fine tunes the cascade in a cell type-specific fashion. Transforming agents utilize this cascade in inducing cell proliferation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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