| Autor: |
D H, Fleming, B S, Mathew, G T, John, S J, Chandy, J, Manivannan, V, Jeyaseelan |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
Journal of postgraduate medicine. 52(4) |
| ISSN: |
0022-3859 |
| Popis: |
Therapeutic drug monitoring for mycophenolic acid (MPA) is increasingly being advocated. The present therapeutic range relates to the 12-hour area under the serum concentration time profile (AUC).However, this is a cumbersome, tedious, cost restricting procedure. Is it possible to reduce this sampling period?To compare the AUC from a reduced sampling strategy with the full 12-hour profile for MPA.Clinical Pharmacology Unit of a tertiary care hospital in South India. Retrospective, paired data.Thirty-four 12-hour profiles from post-renal transplant patients on Cellcept were evaluated. Profiles were grouped according to steroid and immunosuppressant co-medication and the time after transplant. MPA was estimated by high performance liquid chromatography with UV detection. From the 12-hour profiles the AUC up to only six hours was calculated by the trapezoidal rule and a correction factor applied. These two AUCs were then compared.Linear regression, intra-class correlations (ICC) and a two-tailed paired t-test were applied to the data.Comparing the 12-hour AUC with the paired 6-hour extrapolated AUC, the ICC and linear regression(r2) were very good for all three groups. No statistical difference was found by a two-tailed paired t-test. No bias was seen with a Bland Altman plot or by calculation.For patients on Cellcept with prednisolone +/- cyclosporine the 6-hour corrected is an accurate measure of the full 12-hour AUC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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