| Autor: |
O K, Mirzoeva, G F, Sud'ina, M A, Pushkareva, G A, Korshunova, N V, Sumbatian, S D, Varfolomeev |
| Rok vydání: |
1995 |
| Předmět: |
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| Zdroj: |
Bioorganicheskaia khimiia. 21(2) |
| ISSN: |
0132-3423 |
| Popis: |
We have prepared two lipophilic derivatives of caffeic acid at the carboxylic function--caffeic acid phenethyl ester, an active component of propolis, and N,N'-dicyclohexyl-O-(3,4-dihydroxycinnamoyl)-isourea. Both substances inhibit barley 5-lipoxygenase and soybean 15-lipoxygenase at micromolar concentrations. The inhibition is uncompetitive, dose-dependent and reversible. The caffeic acid derivatives also exhibit antioxidant properties and at a concentration 5-10 microM completely block the production of the reactive oxygen species in human neutrophils and in the cell-free xanthine/xanthine oxidase system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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