[Immunomodulating action of terrilytin]
| Autor: | G A, Chalyĭ, L G, Prokopenko, L P, Chalaia |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Erythrocytes
Rosette Formation Dose-Response Relationship Drug Administration Topical Immune Sera Anti-Inflammatory Agents Rats Inbred Strains Rats Drug Combinations Hemagglutinins Adjuvants Immunologic Fibrinolytic Agents Amylases Animals Immunization Antibody-Producing Cells Spleen Peptide Hydrolases |
| Zdroj: | Farmakologiia i toksikologiia. 47(4) |
| ISSN: | 0014-8318 |
| Popis: | When injected intramuscularly in a dose of 10, 20 and 40 proteolytic units terrilitin stimulates the immune response to sheep red blood cells (SRBC). Red cells of rats injected with terrilitin also stimulate the immune response to SRBC in intact syngeneic recipients. Splenocytes of rats injected with terrilitin secrete helper factor to the cultural medium. Supernatant of splenocytes incubated in the presence of red cells of rats injected with terrilitin possess more demonstrable immunostimulant properties than supernatant of splenocytes incubated with or without red cells of intact rats. Splenocytes of rats injected with red cells of rats pretreated with protease form the helper factor. Rat red blood cells treated with serum of animals given terrilitin are capable of inducing the production of the helper factor by splenocytes. |
| Databáze: | OpenAIRE |
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