| Autor: |
D A, Chistiakov, L M, Demurov, Ia Iu, Kondrat'ev, T M, Milen'kaia, G G, Mamaeva, M I, Balabolkin, V V, Nosikov |
| Rok vydání: |
1999 |
| Předmět: |
|
| Zdroj: |
Genetika. 34(12) |
| ISSN: |
0016-6758 |
| Popis: |
The insertion/deletion polymorphism (I/D) of the angiotensin I-converting enzyme gene (ACE) was examined in type I diabetes mellitus patients (DM) with (n = 31), or without (n = 33) retinopathy, and in type 2 DM patients with either myocardial infarction (MI; n = 75), or with (n = 37), or without (n = 178) retinopathy. No association between the ACE gene and retinopathy in type 1 and type 2 DM patients was revealed. In the type 2 DM patients with MI, a statistically significant (P0.05) elevation of the D allele frequency (64%) compared to that without MI (55.3%), together with statistically nonsignificant prevalence of the DD homozygotes (41% versus 30.6%) was observed. Our data indicate that the D allele (RR 1.43) and DD genotype (RR 1.75) are risk factors for myocardial infarction in the type 2 DM patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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