| Autor: |
Monika, Chabicovsky, Eva, Prieschl-Grassauer, Joachim, Seipelt, Thomas, Muster, Oliver H J, Szolar, Alexandra, Hebar, Otto, Doblhoff-Dier |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Basicclinical pharmacologytoxicology. 107(3) |
| ISSN: |
1742-7843 |
| Popis: |
Pyrrolidine dithiocarbamate (PDTC) was examined for its potential in the intranasal treatment of human rhinovirus infections. Prior to clinical testing, a comprehensive non-clinical programme was performed to evaluate the general toxicity of PDTC. The animal experiments included investigations in rodents with study durations ranging from single dose to repeated dosing over a period of 28 days. The routes of administration were intranasal, inhalative, oral and intravenous for single-dose toxicity and pharmacokinetic studies, and intranasal for repeated dose studies. Blood and tissue samples were obtained from PDTC-treated rats to analyse pharmacokinetics and tissue distribution. Accumulation of selected metals due to PDTC treatment was examined in liver, brain, nerves and fat tissues. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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