Innovative treatment programs against cancer: II. Nuclear factor-kappaB (NF-kappaB) as a molecular target

Autor:	K G, Waddick, F M, Uckun
Rok vydání:	1999
Předmět:	Gene Expression Regulation Viral Gene Expression Regulation Cell Survival Transforming Growth Factor beta Drug Design Neoplasms Radiation Ionizing NF-kappa B Animals Humans Models Biological Signal Transduction
Zdroj:	Biochemical pharmacology. 57(1)
ISSN:	0006-2952
Popis:	Nuclear factor-kappaB (NF-kappaB) activity affects cell survival and determines the sensitivity of cancer cells to cytotoxic agents as well as to ionizing radiation. Preventing the protective function of NF-kappaB may result in chemo- and radio-sensitization of cancer cells. Therefore, NF-kappaB has emerged as one of the most promising molecular targets in rational drug design efforts of translational cancer research programs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::34269df82317d084ad26a71e1935f5a0 https://pubmed.ncbi.nlm.nih.gov/9920280 Zobrazit plný text záznamu Full Text from ScienceDirect