| Autor: |
F, Descotes, H, Bittard, M, Bittard, G L, Adessi |
| Jazyk: |
francouzština |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Bulletin du cancer. 80(8) |
| ISSN: |
0007-4551 |
| Popis: |
The c-Ha-ras-1 polymorphism was studied in 92 bladder tumor samples (newly diagnosed and/or recurrent) obtained from 73 patients and in the paired white blood cells (WBC). A heterozygous state was detected in WBC DNA of 38 patients (52%). The statistical analysis (univariate and multivariate) demonstrated an association between the heterozygous state of the patients and a lymphatic invasion. In patients with a pTa tumor, there was a relation between the heterozygous state and a younger age at diagnosis. A loss of heterozygosity for c-Ha-ras-1 locus was detected in seven out of the 38 informative tumors (18.4%). No significant correlation was observed with the prognostic factors. These results address the relation between the heterozygous genomic state and the risk of lymphatic invasion in the patients with a bladder tumor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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