| Autor: |
S V, Chupreta, A L, Evdonin, D V, Tvorogov, N V, Tsupkina, N N, Nikol'nskiĭ, N D, Medvedeva |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Tsitologiia. 40(2-3) |
| ISSN: |
0041-3771 |
| Popis: |
It is shown that phosphoinositide-specific phospholipase C gamma 1 (PLC gamma 1), a substrate of growth factor receptors, is associated with cytoskeleton in A-431 cells. PLC gamma 1 is co-localized only with the cortical actin but not with actin stress fibers. Since EGF receptor is also co-localized with the cortical actin it is concluded that PLC gamma 1 co-localized with actin is mediated by the EGF receptor. After the treatment with cytochalasin B PLC gamma 1 is co-localized with actin aggregates and cytoskeleton elements other than actin. Using double immunofluorescence PLC gamma 1 is shown to be associated with cytokeratin intermediate filaments. The cross-talking of different cytoskeleton elements and their participation in cell signaling is discussed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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