| Popis: |
The effects of different oral contraceptive combined preparations (Serial, Ovanon, Delpregnin, Lyndiol 2.5, Ovulen mite, Primovlar, Gentrol, and Anovlar) on vaginal cytology during different phases of the menstrual cycle were studied. The karyopyknotic index was determined by phase contrast in 1301 patients and in 2213 controls. The results revealed great differences in estrogen activity and individual modes of action of progestin based on the cyclical pattern. It was established that vaginal cytology is an applicable and convenient method of comparing biological and especially estrogenic activities of different OCs as well as the reciprocal effect of different progestational steroids, and it is recommended that this method should be used in testing new preparations. |
