Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression
Autor: | Ebbe, Boedtkjer |
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Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Reviews of physiology, biochemistry and pharmacology. 182 |
ISSN: | 0303-4240 |
Popis: | Solid tumors, including breast carcinomas, are heterogeneous but typically characterized by elevated cellular turnover and metabolism, diffusion limitations based on the complex tumor architecture, and abnormal intra- and extracellular ion compositions particularly as regards acid-base equivalents. Carcinogenesis-related alterations in expression and function of ion channels and transporters, cellular energy levels, and organellar H |
Databáze: | OpenAIRE |
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