| Autor: |
Shi-Xin, Yang, Wen-Song, Wei, Qian-Wen, Ouyan, Qi-Hua, Jiang, Yu-Feng, Zou, Wei, Qu, Jian-Hong, Tu, Zhi-Bing, Zhou, Hao-Long, Ding, Chun-Wei, Xie, Qiu-Mo, Lei, Cheng-Ren, Zhong |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 84 |
| ISSN: |
1950-6007 |
| Popis: |
During the past two decades, cytokines have emerged as key molecules to modulate innate and adaptive immunity and mediate anti-tumor activity. Although multiple cytokine types are implicated for such anti-tumor activity in several cancer types, it remains largely unknown in breast cancer. In this study, cytokines that are prior known for antitumor activity in different cancer types were examined against breast cancer using a 4T1 cells based xenograft-model. Our results showed Interleukin-12 (IL-12) (500ng/mouse) significantly suppressed the growth of tumors, while other cytokines showed minimal suppression. Subsequent molecular analysis by flow cytometry and immunohistochemistry confirmed the CD8 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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