| Autor: |
Yu, Yang, Hui, Xie, Jian-jian, Zheng, Bi-cheng, Chen, Qiu-xiang, He, Ji-hong, Shen |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Zhonghua yi xue za zhi. 90(46) |
| ISSN: |
0376-2491 |
| Popis: |
To study the distribution of alpha1-adrenoceptor (α1-AR) subtype in prostate, posterior urethra and bladder detrusor of patients with chronic prostatitis (CP).The prostate specimens were collected at autopsy from 30 organ donors (aged 20-35 years old) dying of non-prostatic diseases. The pathological specimens of prostate peripheral zone were examined. The method of real-time reverse transcriptase polymerase chain reaction (real-time RT-PCR) was employed for quantification of α1a-AR and α1b-AR subtype expression in prostate transition zone and its surrounding zone, posterior urethra and bladder detrusor tissue.Among all donors, there were 24 cases with pathological inflammation in prostatic peripheral zone and 6 with pathological non-inflammation. The mRNA expression of α1-AR subtypes in bladder detrusor and posterior urethra was significantly higher in the inflammation group than in the control group (P0.05). While the mRNA expression of α1-AR subtypes in the bladder detrusor and posterior urethra was significantly lower in the inflammation group than in the control group (P0.05).An abnormal expression of α1-AR subtypes in bladder detrusor and posterior urethra may explain various urodynamic changes in CP and lead to the occurrence and development of CP in prostate, posterior urethra and bladder detrusor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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