| Autor: |
Angelique C, Paulk, Yoav, Kfir, Arjun R, Khanna, Martina L, Mustroph, Eric M, Trautmann, Dan J, Soper, Sergey D, Stavisky, Marleen, Welkenhuysen, Barundeb, Dutta, Krishna V, Shenoy, Leigh R, Hochberg, R Mark, Richardson, Ziv M, Williams, Sydney S, Cash |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Nature neuroscience. 25(2) |
| ISSN: |
1546-1726 |
| Popis: |
Recent advances in multi-electrode array technology have made it possible to monitor large neuronal ensembles at cellular resolution in animal models. In humans, however, current approaches restrict recordings to a few neurons per penetrating electrode or combine the signals of thousands of neurons in local field potential (LFP) recordings. Here we describe a new probe variant and set of techniques that enable simultaneous recording from over 200 well-isolated cortical single units in human participants during intraoperative neurosurgical procedures using silicon Neuropixels probes. We characterized a diversity of extracellular waveforms with eight separable single-unit classes, with differing firing rates, locations along the length of the electrode array, waveform spatial spread and modulation by LFP events such as inter-ictal discharges and burst suppression. Although some challenges remain in creating a turnkey recording system, high-density silicon arrays provide a path for studying human-specific cognitive processes and their dysfunction at unprecedented spatiotemporal resolution. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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