Fractures Related to Metabolic Bone Disease in Children with Congenital Heart Disease
| Autor: | Henry H, Cheng, Fabio, Carmona, Erica, McDavitt, Daniel, Wigmore, Jeannette M, Perez-Rossello, Catherine M, Gordon, Frank A, Pigula, Peter C, Laussen, Satish K, Rajagopal |
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| Rok vydání: | 2015 |
| Předmět: |
Heart Defects
Congenital Male Time Factors Critical Illness Hyperparathyroidism Age Factors Infant Length of Stay Hospitals Pediatric Risk Assessment Bone Diseases Metabolic Fractures Bone Calcitriol Clinical Protocols Parathyroid Hormone Risk Factors Infant Mortality Humans Female Hospital Mortality Biomarkers Boston Retrospective Studies |
| Zdroj: | Congenital heart disease. 11(1) |
| ISSN: | 1747-0803 |
| Popis: | Critically ill children with congenital heart disease (CHD) are at risk for metabolic bone disease (MBD) and bone fractures. Our objective was to characterize a cohort of CHD patients with fractures and describe a Fragile Bone Protocol (FBP) developed to reduce fractures.Patients who developed fractures in the Cardiac Intensive Care Unit (CICU) of Boston Children's Hospital from 3/2008 to 6/2014 were identified via quality improvement and radiology databases. The FBP (initiated July 2011) systematically identifies patients at risk for MBD and prescribes special handling precautions.Twenty-three fractures were identified in 15 children. Median age at fracture identification was 6.2 months, with a median duration of hospitalization before fracture diagnosis of 2.7 months. Six patients (40%) had single ventricle CHD. Hyperparathyroidism and low 25-OH vitamin D levels were present in 77% and 40% of those tested, respectively. Compared with patients not diagnosed with fractures, fracture patients had increased exposure to possible risk factors for MBD and had elevated parathyroid and decreased calcitriol levels.Six patients (40%) did not survive to hospital discharge, compared with an overall CICU mortality rate of 2.6% (P.01). The fracture case rate before implementation of the FBP was 2.6 cases/1000 admissions and was 0.7/1000 after implementation of the FBP (P = .04).Critically ill CHD patients are at risk for fractures. They represent a complex group who frequently has hyperparathyroidism and decreased calcitriol levels, and each may predispose to fractures. FBPs consisting of identification and careful patient handling should be considered in at-risk patients. |
| Databáze: | OpenAIRE |
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