| Autor: |
Hussein, Alnajar, Hiranmayi, Ravichandran, André, Figueiredo Rendeiro, Kentaro, Ohara, Wael, Al Zoughbi, Jyothi, Manohar, Noah, Greco, Michael, Sigouros, Jesse, Fox, Emily, Muth, Samuel, Angiuoli, Bishoy, Faltas, Michael, Shusterman, Cora N, Sternberg, Olivier, Elemento, Juan Miguel, Mosquera |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Cold Spring Harbor molecular case studies. 8(3) |
| ISSN: |
2373-2873 |
| Popis: |
Sarcomatoid urothelial carcinoma (SUC) is a rare subtype of urothelial carcinoma (UC) that typically presents at an advanced stage compared to more common variants of UC. Locally advanced and metastatic UC have a poor long-term survival following progression on first-line platinum-based chemotherapy. Antibodies directed against the programmed cell death 1 protein (PD-1) or its ligand (PD-L1) are now approved to be used in these scenarios. The need for reliable biomarkers for treatment stratification is still under research. Here, we present a novel case report of the first Imaging Mass Cytometry (IMC) analysis done in SUC to investigate the immune cell repertoire and PD-L1 expression in a patient who presented with metastatic SUC and experienced a prolonged response to the anti-PD1 immune checkpoint inhibitor pembrolizumab after progression on first-line chemotherapy. This case report provides an important platform for translating these findings to a larger cohort of UC and UC variants. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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