DS6: anticandidal, antibiofilm peptide against Candida tropicalis and exhibit synergy with commercial drug

Autor:	Kusum, Singh, Shashank, Shekhar, Yudhishthir, Yadav, Immaculata, Xess, Sharmistha, Dey
Rok vydání:	2016
Předmět:	Antifungal Agents Erythrocytes Cell Survival Amino Acid Motifs Drug Synergism Microbial Sensitivity Tests Drug Combinations HEK293 Cells Species Specificity Amphotericin B Biofilms Humans Candida tropicalis Peptides Fluconazole Solid-Phase Synthesis Techniques Candida
Zdroj:	Journal of peptide science : an official publication of the European Peptide Society. 23(3)
ISSN:	1099-1387
Popis:	Antifungal peptides have gained interest as therapeutic agents in recent years because of increased multidrug resistance against present antifungal drugs. This study designed, synthesized and characterized antifungal activity of a small peptide analogue, DS6. This peptide was designed using the template from the N-terminal part of the antifungal protein, Aspergillus giganteous. DS6 inhibited Candida tropicalis (ATCC 13803), as well as its clinical isolates. DS6 was found to be a fungicidal, killing the fungus very rapidly. DS6 is also non-toxic to human cells. Synergistic interactions of DS6 with amphotericin B and fluconazole were also evident. DS6 is membrane lytic and exhibits antibiofilm activity against C. tropicalis. In conclusion, DS6 may have utility as an alternative antifungal therapy for C. tropicalis. Copyright © 2017 European Peptide Society and John WileySons, Ltd.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::324f3f75526743969675f029c50ee14f https://pubmed.ncbi.nlm.nih.gov/28120548 Zobrazit plný text záznamu Plný text