| Autor: |
Qing-Zhao, Li, Juan, Peng, Hai-Mei, Chen, Zhen-Zhen, Chen, Zhan-Wang, Zhu, Ling-Shu, Li, Guo-Yu, Hu, Zhao-Hui, Yuan |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Zhongguo shi yan xue ye xue za zhi. 30(6) |
| ISSN: |
1009-2137 |
| Popis: |
To study the expression and significance of PD-1, PD-L1 and CTLA-4 tumor-associated antigens in multiple myeloma.Bone marrow specimens from 122 patients with multiple myeloma were collected and divided into new-onset group (NDMM), complete remission group (CRMM) and relapsed and refractory group (RRMM) according to the disease progression stage. The proportion of CD4There was no significant difference in the proportion of CD8There is a correlation between the immune status of multiple myeloma and the expressions of PD-1, PD-L1 and CTLA-4 in plasma cells and lymphocyte subsetsPD-1、PD-L1和CTLA-4在多发性骨髓瘤患者骨髓中的表达与意义.研究PD-1、PD-L1和CTLA-4肿瘤相关抗原在多发性骨髓瘤中的表达及意义.收集多发性骨髓瘤患者骨髓标本122份，根据患者疾病的进展阶段分为新发（NDMM）、完全缓解（CRMM）和复发难治（RRMM）共3组。利用多参数流式细胞仪检测标本中CD4不同阶段MM患者间CD8多发性骨髓瘤的免疫状态与体内浆细胞和各淋巴细胞亚群中PD-1、PD-L1及CTLA-4的表达情况存在相关关系. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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