In vivo comparison of N

Autor: J S, Dileep Kumar, Jaya, Prabhakaran, Naresh, Damuka, Justin Wayne, Hines, Skylar, Norman, Meghana, Dodda, J, John Mann, Akiva, Mintz, Kiran Kumar Solingapuram, Sai
Rok vydání: 2019
Předmět:
Zdroj: Bioorganicmedicinal chemistry letters. 30(2)
ISSN: 1464-3405
Popis: Altered dynamics of microtubules (MT) are implicated in the pathophysiology of a number of brain diseases. Therefore, radiolabeled MT targeted ligands that can penetrate the blood brain barrier (BBB) may offer a direct and sensitive approach for diagnosis, and assessing the clinical potential of MT targeted therapeutics using PET imaging. We recently reported two BBB penetrating radioligands, [
Databáze: OpenAIRE