| Autor: |
L, Annino, A, Ferrari, L, Laurenti, M P, Perrone, C, Romani, A, Pacchiarotti, G, Girelli, F, Mandelli |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Leukemialymphoma. 14 |
| ISSN: |
1042-8194 |
| Popis: |
In HCL patients some cases of familial occurrence of the disease were reported, without an association with a specific haplotype or HLA antigen. In a series of a non familial HCL patients an increase in DR11 frequency was reported. We performed HLA class I and class II antigens in a series of 38 consecutive HCL patients. An increased frequency of B17 (10/38-27%) and DR11 (22/38-57%) antigens compared with the normal Caucasian population was recorded. As clinical characteristics, no significant differences were recognized between DR11 positive and DR11 negative patients. In response to IFN treatment, a complete response (CR) was achieved in 20% of DR11 patients and in 46% of DR11 negative patients. In this study an increase frequency of B17 and DR11 antigens was found; furthermore DR11 positive patients seem to be less responsive to IFN treatment but a larger series of patients will have to be studied in the future in order to establish this observation with more certainty. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
