| Autor: |
S T, Roodman, M D, Woon, J W, Hoffmann, P, Theodorakis, C C, Tsai, H N, Wu |
| Rok vydání: |
1991 |
| Předmět: |
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| Zdroj: |
Journal of medical primatology. 20(4) |
| ISSN: |
0047-2565 |
| Popis: |
We investigated the role of Interleukin-6 (IL-6) as an autocrine growth factor for the retroperitoneal fibromatosis (RF) cells present in macaques infected with the simian retrovirus type 2 (SRV-2). Elevated levels of IL-6 were found in serum of SRV-2 antibody-positive macaques, ascites from RF-positive animals, and RF cell line culture media. IL-6 mRNA levels increased approximately five-fold in RF cells incubated with exogenous SRV-2. In RF cells, SRV-2 functions to increase IL-6 mRNA and protein production and presumably serves as autocrine growth factor. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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